Abcam, ab68807, Anti-GIYD2 antibody

Size: 50µg
Mouse Polyclonal GIYD2 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SLX1A.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human SLX1A.Q9BQ83

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GIYD2 also known as GID complex subunit 2 is a protein with a molecular mass of approximately 36 kDa. This protein belongs to a family of proteins that contain the GYF domain involved in protein-protein interactions. GIYD2 shows expression in various tissues with significant presence in the brain liver and kidneys. The protein plays a role in maintaining cellular processes by potentially interacting with other proteins through its GYF domain.
Biological function summary
The GIYD2 protein functions within the GID complex which participates in the degradation of specific proteins via the ubiquitin-proteasome system. This process involves tagging target proteins with ubiquitin molecules directing them to the proteasome for degradation. The activity of GIYD2 within the complex ensures that levels of particular proteins are kept in check facilitating normal cellular functions and responses. The proper function of GIYD2 helps prevent the accumulation of dysfunctional or unnecessary proteins in the cell.
Pathways
GIYD2 interacts in the ubiquitin-mediated proteolysis pathway influencing protein turnover in the cell. Its action is related to the action of ubiquitin ligases such as UBR1 which assists in recognizing proteins marked for degradation. GIYD2 also impacts the cell cycle pathway by regulating the stability of specific cell cycle regulators linking it to proteins involved in cell division and growth such as cyclins and cyclin-dependent kinases.
GIYD2 has connections to neurodegeneration and liver diseases where protein homeostasis is disrupted. Abnormal GIYD2 function may impact levels of proteins influencing neurodegenerative disorders like Alzheimer's disease in association with proteins such as tau. In liver diseases its involvement in protein degradation may affect responses to cellular stress and damage interacting with cellular stress response elements including heat shock proteins.