Abcam, ab69036, Anti-TINAGL1 antibody

Size: 50µg
Mouse Polyclonal TINAGL1 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TINAGL1.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human TINAGL1.Q9GZM7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TINAGL1 also known as Tubulointerstitial Nephritis Antigen Like 1 is an extracellular matrix protein with an approximate mass of 52 kDa. The protein also referred to as TIN-ag localizes primarily in kidney tissues but presents in other tissues like the lung and heart. It associates in the basement membranes of these tissues playing a significant mechanical role in structural integrity and cellular frameworks.
Biological function summary
TINAGL1 facilitates protein interactions that modulate cellular adhesion and migration. It does not belong to any known larger protein complexes but still plays an essential role in maintaining cellular structures. Furthermore TINAGL1 contributes to processes such as angiogenesis and tumor suppression through its interaction with matrix proteins and signaling receptors.
Pathways
TINAGL1 engages in important signaling cascades including the integrin-mediated pathway and the PI3K/Akt pathway. Within these pathways TINAGL1's function closely ties to integrins a group of proteins pivotal for cell adhesion and signal transduction. The protein works alongside fibronectin and collagen establishing pivotal communication for cellular responses to environmental cues.
TINAGL1 involvement extends to certain renal conditions and cancer types. Specifically in kidney diseases like glomerulonephritis TINAGL1 interaction with nephronectin may influence disease progression. In cancer it associates with various oncogenes offering potential as a tumor suppressor in breast cancer where it interacts with proteins like laminin. Such relationships highlight TINAGL1's potential as a target for developing novel therapeutic strategies.