Abcam, ab69226, Anti-NETO1 antibody

Size: 50µg
Mouse Polyclonal NETO1 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NETO1.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human NETO1.Q8TDF5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The NETO1 protein also known as Neuropilin and Tolloid-like 1 is a transmembrane protein with a molecular weight of about 75 kDa. It is primarily expressed in the central nervous system particularly in the hippocampus and cerebellum. NETO1 serves as an auxiliary subunit of ionotropic glutamate receptors specifically the kainate receptor. It modulates the receptor's function by enhancing its kinetics and gating critical for synaptic transmission and plasticity.
Biological function summary
The protein interacts with kainate receptors forming a functional receptor complex that aids in neurotransmission processes. The complex plays a significant role in synaptic scaling and has implications for learning and memory functions. NETO1's ability to bind to various ligands on the glutamate receptor ensures its engagement in critical signal transduction activities across neuronal synapses.
Pathways
The function of NETO1 integrates into neurotransmission and synaptic plasticity pathways. NETO1 plays an important role in the glutamatergic synaptic transmission pathway alongside proteins like the GLUR5 receptor subunit. This involvement facilitates efficient communication between neurons influencing long-term potentiation and depression which are central to learning and memory processes.
NETO1's dysfunction associates with neurological and psychiatric conditions such as schizophrenia and epilepsy. Altered expression or mutations in NETO1 can impact the signaling pathway affecting synaptic strength and neuronal communication. It also interacts with proteins such as DLG4 also known as PSD-95 in these conditions further implicating NETO1 in the stability and function of postsynaptic densities potentially leading to cognitive and behavioral abnormalities.