Abcam, ab69232, Anti-Pseudomonas aeruginosa serotype 5c antibody [SD6930]

Size: 100µL
Mouse Monoclonal Pseudomonas aeruginosa serotype 5c antibody. Suitable for ELISA, ICC/IF and reacts with Pseudomonas aeruginosa samples. Cited in 3 publications. Immunogen corresponding to Cell preparation containing Pseudomonas aeruginosa serotype 5c protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:SD6930,
Isotype:IgG1,
Carrier free:No,
Reacts with:Pseudomonas aeruginosa,
Applications:ELISA, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.065% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pseudomonas aeruginosa serotype 5c is a lipopolysaccharide antigen found on the outer membrane of the Pseudomonas aeruginosa bacterium. This serotype is associated with the specific O-antigen portion of the bacterial lipopolysaccharide but does not have an alternate name. The molecular mass for this lipopolysaccharide varies due to its complex structure. Pseudomonas aeruginosa serotype 5c is expressed on the cell surface where it plays a significant role in bacterial immune evasion and survival in hostile environments.
Biological function summary
This serotype contributes to the bacterium's ability to resist phagocytosis and avoid detection by the host’s immune system. It is not part of a multiprotein complex but interacts directly with components of the host immune system. The structure of the lipopolysaccharide helps in maintaining bacterial structural integrity and can trigger inflammatory responses from the host.
Pathways
Pseudomonas aeruginosa serotype 5c engages in pathways involving bacterial defense mechanisms and host-pathogen interactions. It plays a part in the lipopolysaccharide biosynthesis pathway which involves several enzymes responsible for the assembly of this complex molecule. It also participates in signaling pathways that modulate the host immune response indirectly interacting with immune-related proteins such as TLR4 which is a receptor in innate immunity pathways.
Pseudomonas aeruginosa serotype 5c is strongly linked to respiratory infections like pneumonia especially in immunocompromised individuals. This serotype significantly contributes to the virulence and persistence of the bacteria in diseases like cystic fibrosis due to its resistance to host defense mechanisms. Chronic colonization in the respiratory tract often involves interactions with host proteins including CFTR a protein affecting mucus clearance in cystic fibrosis compounding the disease's severity.