Abcam, ab69236, Anti-Serratia marcescens antibody [B/N4N]

Size: 100µL
Mouse Monoclonal Serratia marcescens antibody. Suitable for ELISA, ICC/IF and reacts with Serratia marcescens samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing Serratia marcescens protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:B/N4N,
Isotype:IgG1,
Carrier free:No,
Reacts with:Serratia marcescens,
Applications:ICC/IF, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.065% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Serratia marcescens is a Gram-negative bacterium that often exists in water soil and as a part of the human microbiota. Known commonly for its reddish pigment prodigiosin this bacterium exhibits a variety of mechanical actions including quorum sensing secretion of virulence factors and motility. These actions involve a combination of surface-expressed proteins and enzymes. With a mass particular to its structure S. marcescens demonstrates flexibility in occupying diverse environments including hospital settings where it can become opportunistic.
Biological function summary
Serratia marcescens plays a role in infection processes due to its secretion of extracellular enzymes such as proteases lipases and DNases enhancing its pathogenic capabilities. The bacterium is part of biofilm-forming complexes that contribute to its resilience against environmental stress. This ability to form biofilms increases its persistence in medical devices and surfaces complicating treatment of infections it causes.
Pathways
Serratia marcescens participates in mechanisms that involve quorum sensing networks particularly through the SmaI/SmaR system akin to LuxI/LuxR systems found in other bacteria. This involves the synthesis and detection of signaling molecules regulating gene expression related to virulence and biofilm formation. The bacterium links to other bacterial proteins that modulate these pathways facilitating communication and coordination among microbial communities.
Serratia marcescens is associated with opportunistic infections such as urinary tract infections and pneumonia often in immunocompromised individuals. The bacterium's interaction with host proteins like mannose-binding lectin can influence its pathogenicity. Its ability to produce multiple antibiotic resistance through chromosomal mutations further complicates treatment making S. marcescens a challenging target in clinical microbiology.