Abcam, ab69392, Anti-CYP4V2 antibody

Size: 50µg
Mouse Polyclonal CYP4V2 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Cytochrome P450 4V2.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human Cytochrome P450 4V2.Q6ZWL3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CYP4V2 also known as cytochrome P450 family 4 subfamily V member 2 is an enzyme with a molecular mass of approximately 61 kDa. This protein functions as part of the cytochrome P450 superfamily specifically catalyzing the oxidation of fatty acids and steroid metabolism. CYP4V2 is expressed in various tissues especially prominent in the retina. It helps in the biochemical processes involving lipid metabolism important for maintaining cellular homeostasis.
Biological function summary
CYP4V2 plays a significant role in the metabolism of long-chain fatty acids. It does not form part of a larger complex but functions independently to influence the metabolism pathways critical for maintaining normal visual function. Its activity is essential for processing specific fatty acids that accumulate due to metabolic dysfunction which can lead to cellular damage if not properly managed.
Pathways
The enzyme participates notably in the omega-hydroxylation pathway important for lipid processing. The long-chain fatty acids are metabolized through reactions facilitated by CYP4V2 which ensures the regulation of lipid synthesis and degradation. Alongside other members of the cytochrome P450 family such as CYP4A11 CYP4V2 maintains systemic balance through these processes.
CYP4V2 mutation is closely linked to Bietti's crystalline dystrophy a retinal degenerative disease causing vision impairment. This connection highlights its critical function in retinal lipid metabolism. The disruption in the normal function of CYP4V2 impacts the homeostatic mechanisms similar disorders may synergistically involve proteins such as ABCA4 contributing to the pathogenesis of retinal deterioration. Understanding these interactions is important for developing targeted disease-modifying therapies.