Abcam, ab69470, Anti-NARS2 antibody

Size: 50µg
Mouse Polyclonal NARS2 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NARS2.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human NARS2.Q96I59

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NARS2 also known as mitochondrial asparaginyl-tRNA synthetase is a protein with a mass of approximately 51 kDa. It plays an important role in the process of protein synthesis within the mitochondria by attaching asparagine to its corresponding tRNA. NARS2 is expressed in tissues with high energy demands such as the heart muscle and brain. These areas highlight its importance in cellular energy production and metabolism.
Biological function summary
NARS2 functions in aminoacyl-tRNA biosynthesis. It is part of a group of enzymes called the aminoacyl-tRNA synthetases which are essential for the translation of the genetic code into proteins. This enzyme is involved in adding specific amino acids to their corresponding tRNAs therefore ensuring the accurate translation of mitochondrial mRNA into functional proteins. The precise function of NARS2 supports overall mitochondrial activity and energy production emphasizing its role in cellular health.
Pathways
NARS2 is critically involved in the mitochondrial translation pathway. This pathway is important for the proper functioning of the electron transport chain and ATP production. NARS2 works alongside other aminoacyl-tRNA synthetases and mitochondrial translation initiation factors to facilitate protein synthesis in mitochondria. Its activity directly impacts proteins such as the respiratory chain complex proteins which are necessary for efficient cellular respiration.
NARS2 mutations have been linked to mitochondrial diseases including mitochondrial encephalomyopathy and sensorineural hearing loss. These conditions result from impaired mitochondrial protein synthesis leading to reduced energy output. One related protein affected in these disorders is the complex I protein of the electron transport chain as its synthesis depends on proper mitochondrial function. NARS2's connection to these conditions emphasizes the importance of proper mitochondrial translation in maintaining cellular energy balance.