Abcam, ab69484, Anti-Cathelicidin/CLP antibody

Size: 100µg
Rabbit Polyclonal Cathelicidin/CLP antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Human samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human CAMP aa 50-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CAMP aa 50-100. The exact immunogen used to generate this antibody is proprietary information.P49913,
Specificity:There is 71% homology between the immunogen and mouse cathelicidin/CLP. This antibody has been published (see PubMed: 21724991) with mouse samples, but we were unable to see an appropriately sized band in mouse spleen or small intestine by WB. It may be that certain lots have worked with mouse, but we are unable to guarantee cross-reactivity with mouse after our testing.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cathelicidin also known as LL-37 peptide is an antimicrobial peptide with a mass of around 18 kDa. It plays an important role in the innate immune system by disrupting microbial membranes. LL-37 is expressed in various tissues including skin mucosal surfaces and certain immune cells. These peptides protect the host from infection by directly killing bacteria viruses and fungi and by modulating immune responses.
Biological function summary
Peptides like Cathelicidin are essential for host defense mechanisms contributing to cell signaling and pathogen clearance. LL-37 does not function within a complex but acts independently to influence immune cell chemotaxis. It promotes wound healing angiogenesis and tissue repair thereby ensuring rapid response to injury or infection.
Pathways
Cathelicidin interacts within inflammatory and wound healing pathways. It is involved in the NF-kB signaling pathway which regulates immune response and is linked to TLR (Toll-like receptor) pathways impacting cytokine production and further immune modulation. Proteins such as defensins share similar pathways indicating their collective influence in antimicrobial defense and tissue repair.
Peptides like Cathelicidin are associated with conditions like psoriasis and atopic dermatitis. Overexpression or dysregulation of LL-37 can exacerbate inflammation in these autoimmune skin disorders. Related to these diseases proteins such as interleukins (IL-1 and IL-6) are often co-expressed or influenced by Cathelicidin levels indicating their intertwined role in skin homeostasis and immune responses.