Abcam, ab69611, Anti-COX17 antibody

Size: 100µg
Rabbit Polyclonal COX17 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human COX17.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human COX17. The exact immunogen used to generate this antibody is proprietary information.Q14061

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
COX17 also known as Cytochrome c oxidase copper chaperone plays a mechanical role by providing copper ions to cytochrome c oxidase in mitochondria. It weighs approximately 8 kDa and is expressed in various tissues with a higher presence in heart and skeletal muscle tissues. This small protein ensures the proper functioning of cytochrome c oxidase through copper ion delivery an essential process for mitochondrial energy production.
Biological function summary
COX17 assists in the formation and stabilization of the cytochrome c oxidase complex a critical component of the mitochondrial electron transport chain. As part of this complex COX17 ensures efficient electron transfer and ATP production by donating copper ions to support the catalytic activity. Proper cytochrome c oxidase function maintains cellular respiration and energy synthesis which is necessary for cellular vitality and health.
Pathways
COX17 is involved in the mitochondrial electron transport chain and copper ion homeostasis pathways. These pathways are vital for maintaining cellular energy levels and regulating copper distribution within cells. COX17 interacts with other proteins such as COX11 and COX17 plays an essential supportive role alongside COX11 ensuring cytochrome c oxidase assembles correctly and functioning optimally to utilize oxygen effectively.
COX17 has a connection with mitochondrial disorders and neurodegenerative conditions. Mutations or dysfunctions in COX17 can lead to deficits in cellular energy production contributing to conditions like Leigh syndrome and some forms of muscular dystrophy. Its interaction with cytochrome c oxidase makes abnormalities in COX17 relevant to cytochrome c oxidase deficiency implicating it in diseases influenced by mitochondrial malfunction.