Abcam, ab70183, Anti-KAT7 / Hbo1 / MYST2 antibody

Size: 100µg
Rabbit Polyclonal KAT7 / Hbo1 / MYST2 antibody. Suitable for IP, ELISA, WB, ICC/IF, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 19 publications. Immunogen corresponding to Synthetic Peptide within Human KAT7.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:ELISA, WB, IP, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human KAT7. The exact immunogen used to generate this antibody is proprietary information.O95251

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KAT7 also known as Hbo1 KAT-7 MYST2 KAT-7 and Katset functions as a histone acetyltransferase specifically modifying histone H4 at lysine 12 5 and 8. With a molecular mass typically around 63 kDa KAT7 is expressed in nucleus and localizes to chromatin. It associates with chromatin during DNA replication and is vital in histone H4 acetylation facilitating chromatin remodeling and gene expression.
Biological function summary
This protein plays a significant role in transcription regulation and DNA replication. KAT7 is a component of the HBO1 complex working together with other proteins like JADE1/2/3 BRPF1/2/3 and ING4/5 making it integral to cell cycle progression and transcriptional activation. This complex is essential for initiating DNA replication as it acetylates histones and regulates chromatin accessibility necessary for DNA synthesis.
Pathways
KAT7/Hbo1/MYST2 is actively engaged in the transcriptional regulatory network and DNA replication pathways. It influences gene expression through its interaction with the transcriptional machinery and by modifying the chromatin structure. Within these pathways it interacts with proteins like BRPF1 and ING5 enhancing transcription and replication. This positions KAT7 as an important component in ensuring cellular growth and division through its histone acetylation activities.
Research indicates a link between KAT7 function and cancer. Its dysregulation contributes to tumorigenesis related to its role in cell proliferation and gene expression. KAT7 affects the expression of oncogenes and interacts with proteins like p53. Altered KAT7 activity disrupts normal cellular processes and in cancer results in aberrant cell cycle regulation and uncontrolled cell proliferation highlighting its potential as a therapeutic target in oncology.