Abcam, ab70272, Anti-DOCK9/Trg antibody

Size: 50µL
Rabbit Polyclonal DOCK9/Trg antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DOCK9 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DOCK9 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9BZ29

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DOCK9 also known as Dedicator of Cytokinesis 9 functions as a guanine nucleotide exchange factor (GEF) specifically for the Rho family GTPases including CDC42. This protein has a molecular mass of approximately 250 kDa. DOCK9 is expressed in various tissues including high expression in the brain and lymphoid tissues. Its role primarily involves facilitating the exchange of GDP for GTP on GTPases which is important for signal transduction and cellular morphology.
Biological function summary
DOCK9 regulates cytoskeletal organization and is part of a protein complex that influences actin polymerization. By activating CDC42 DOCK9 contributes to cellular processes such as migration proliferation and immune response. Its activity affects the modulation of actin filaments which is essential for the maintenance of cell shape and the formation of cellular protrusions such as filopodia.
Pathways
DOCK9 has significant roles in both the PI3K-Akt signaling pathway and the Rho GTPase cycle. In these pathways DOCK9 interacts with proteins that determine cell survival growth and motility. CDC42 influences both pathways interacting with other related proteins like RAC1 which further emphasizes the importance of DOCK9 in pathways regulating cell dynamics and receptor signaling.
DOCK9 links to conditions like cancer and immunodeficiency. Alterations in its regulation or expression can lead to aberrant cell migration and proliferation contributing to tumorigenesis. Additionally DOCK9's involvement in activating CDC42 associates it with immunological dysfunctions. Changes in the CDC42 pathway can result in disrupted immune cell activity and development leading to immune-related disorders.