Abcam, ab70334, Anti-PRKRIR antibody

Size: 100µL
Rabbit Polyclonal PRKRIR antibody. Suitable for IHC-P, IP, WB and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human THAP12.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human THAP12. The exact immunogen used to generate this antibody is proprietary information.O43422

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PRKRIR also known as PRK receptor-interacting protein or P58IPK plays a role mechanically as an important component of cellular stress response mechanisms. It acts mainly as an inhibitor of eIF2α phosphorylation which is key to controlling protein synthesis during stress conditions. PRKRIR has an approximate molecular mass of 58 kDa. Researchers have found its expression in various tissues including heart liver and brain. The protein forms a part of cellular response machinery to modulate how cells react to stressors like viral infections or endoplasmic reticulum stress.
Biological function summary
The function of PRKRIR centers on managing cellular stress responses and mitigating apoptosis. It interacts with and regulates the activity of PKR (protein kinase R) a part of the integrated stress response (ISR). As part of its regulatory duties PRKRIR ensures that cells do not overreact to stress signals that might otherwise lead to unnecessary apoptosis. PRKRIR participates as a chaperone-like protein interacting within a complex that ensures the appropriate folding and function of several target proteins engaged in stress adaption pathways.
Pathways
PRKRIR engages in the integrated stress response (ISR) and the unfolded protein response (UPR) pathways. Within these pathways PRKRIR primarily functions to help control the phosphorylation of eIF2α a process heavily regulated under stress conditions to minimize protein synthesis and optimize stress adaptation. It interacts closely with other proteins like PKR and BiP (Binding Immunoglobulin Protein) to modulate these cellular defense mechanisms. By regulating phosphorylation events PRKRIR helps cells to balance survival and apoptotic signals in response to stressful stimuli.
PRKRIR has a significant role in conditions such as neurodegenerative diseases and cancer. In neurodegenerative disorders its role in modulating the ISR could influence neuronal cell survival where dysregulated stress response pathways contribute to disease progression. Cancer research suggests that PRKRIR might be involved in tumor progression where its regulation of protein synthesis can affect cell proliferation rates. Connections to proteins like PKR and eIF2α indicate that altering PRKRIR function can have downstream effects on cellular responses central to disease pathology. Understanding its role offers potential therapeutic interest in designing drugs that modulate stress responses in these disorders.