Abcam, ab70548, Anti-53BP2/ASPP2/BBP antibody

Size: 100µL
Rabbit Polyclonal 53BP2/ASPP2/BBP antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TP53BP2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TP53BP2. The exact immunogen used to generate this antibody is proprietary information.Q13625

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
53BP2 also known as ASPP2 or BBP is a protein that interacts with the p53 tumor suppressor. It has a mass of approximately 140 kDa and is expressed in various tissues including the brain liver and lung. Mechanically 53BP2 modulates the activity of p53 influencing cellular apoptosis. The protein consists of several domains such as ankyrin repeats and SH3 domain that facilitate its interaction with multiple partners enhancing its regulatory function.
Biological function summary
53BP2 plays a role in apoptosis and cell cycle control. It acts as a co-activator in the p53 signaling pathway promoting the pro-apoptotic functions of p53. This protein forms part of a complex network involving p53 and other regulatory molecules which ultimately governs important cellular processes like growth arrest and death. By enhancing p53 transcriptional activity 53BP2 aids in maintaining cellular homeostasis and preventing uncontrolled cell proliferation.
Pathways
53BP2 is primarily involved in the p53 signaling and apoptosis pathways. It works closely with key proteins such as p53 and Bcl-2 enhancing the apoptotic response. In the p53 pathway 53BP2 strengthens p53's ability to transactivate genes essential for apoptosis while in the apoptotic pathway it interacts with members of the Bcl-2 family to regulate mitochondrial events leading to cell death.
53BP2's function is relevant in cancer and neurodegenerative diseases. In cancer dysregulation of 53BP2 function or expression can lead to impaired apoptotic response contributing to tumorigenesis. It is linked to proteins like p53 and Bcl-2 in the context of cancer. In neurodegenerative diseases alterations in 53BP2 activity can affect neuronal cell survival with potential connections to proteins involved in synaptic pathways and apoptotic regulation.