Abcam, ab70599, Anti-HIVEP2 antibody [2418C2a]

Size: 100µg
Mouse Monoclonal HIVEP2 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HIVEP2.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2418C2a,
Isotype:IgG1,
Carrier free:No,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human HIVEP2.P31629

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-ab70599 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum and filtered through a 0.22µm membrane., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: 1% BSA, 0.812% Sodium chloride, 0.1312% Sodium phosphate, 0.1136% Disodium hydrogenorthophosphate, 0.03% Tripotassium orthophosphate, 0.0225% Potassium chloride, 0.0204% Potassium phosphate monobasic, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HIVEP2 also known as Zinc Finger Transcription Factor influences transcription processes by binding to specific DNA sequences. This protein weighs approximately 568 kDa. It primarily appears in the brain and heart with notable expression in these tissues. HIVEP2 acts as a vital component in regulating transcription factors and it plays a significant role in the transcriptional regulation of immune-related genes.
Biological function summary
HIVEP2 regulates gene expression essential for normal cellular functions. Researchers identified it as a part of transcription complexes that control the expression of several immune and developmental genes. Through its zinc finger domains HIVEP2 binds to NF-kB DNA binding sites and influences immune response and inflammatory pathways. These interactions make it a critical component in modulating genes essential for cellular homeostasis and response to stimuli.
Pathways
The HIVEP2 protein participates in NF-kB signaling and Wnt signaling pathways. In these pathways HIVEP2 partners with other proteins like RELA and TCF7L2 to mediate cellular processes such as inflammatory responses and development. These pathways are important for maintaining cellular responses to extrinsic and intrinsic signals establishing HIVEP2 as a critical modulator in maintaining cellular integrity.
HIVEP2 relates to neurodevelopmental disorders and certain cancers. Alterations in HIVEP2 expression or function can link to intellectual disability and developmental delay due to its role in brain development. Furthermore its involvement in NF-kB signaling connects it to inflammatory pathways implicated in tumorigenesis. HIVEP2 interacts with proteins like RELA in these pathways underlying its importance in disease mechanisms and potential therapeutic targets.