Abcam, ab70634, Anti-PPP6C/Ppv antibody

Size: 100µL
Rabbit Polyclonal PPP6C/Ppv antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PPP6C.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PPP6C. The exact immunogen used to generate this antibody is proprietary information.O00743

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PPP6C also known as Protein Phosphatase 6 Catalytic Subunit is a protein phosphatase which participates in dephosphorylation processes. It has a molecular mass of approximately 35 kDa. PPP6C locates mainly in the cytoplasm but has also been found in the nucleus. Its expression is widespread across various tissues including the brain heart and skeletal muscle. PPP6C is important in controlling cellular functions by removing phosphate groups from target molecules influencing their activity state.
Biological function summary
The protein influences cell cycle regulation cell proliferation and apoptosis. This protein typically functions as part of a larger enzymatic complex that includes regulatory and scaffold subunits. By associating with these proteins PPP6C gains specificity towards its substrates and ensures precise cellular responses. Its activity helps maintain cellular homeostasis and proper cell growth and it also modulates immune response pathways by controlling phosphatase activity which is especially critical for immune system functioning.
Pathways
PPP6C interacts with key cellular signaling pathways such as the NF-kB and AKT pathways. During the regulation of these pathways PPP6C associates with proteins like IKK and PDK1 respectively which are important in mediating responses to external stimuli and regulating cell survival. Inhibition or dysregulation of PPP6C can impact these pathways leading to aberrant signaling and altered cellular outcomes. PPP6C's influence on these pathways highlights its role in fine-tuning cellular responses to diverse signals.
PPP6C has connections to melanoma and multiple myeloma. Mutations affecting PPP6C may lead to abnormal protein function contributing to the development of these cancers. For example in melanoma alterations in PPP6C can disrupt cellular signaling pathways often in coordination with related proteins like BRAF and NRAS. Understanding these interactions and their effects on disease progression can provide insights into cancer therapeutics and the development of targeted treatments.