Abcam, ab70723, Anti-SHARP2/DEC1 antibody

Size: 100µL
Rabbit Polyclonal SHARP2/DEC1 antibody. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human BHLHE40.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human BHLHE40. The exact immunogen used to generate this antibody is proprietary information.O14503

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab70723 was affinity purified using an epitope specific to SHARP2/DEC1 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SHARP2 also known as DEC1 or BHLHE40 is a basic helix-loop-helix transcription factor with a molecular weight of approximately 39 kDa. This protein primarily regulates gene expression by binding to E-box sequences in the promoter regions of target genes. SHARP2/DEC1 expression occurs in various tissues such as the brain heart and lungs indicating its involvement in diverse physiological processes. The protein functions as a repressor and modulator of different genes linked to development and cellular responses to environmental changes.
Biological function summary
This transcription factor plays a significant role in the regulation of circadian rhythms and cell cycle progression. SHARP2/DEC1 interacts with various proteins to form complexes that influence cell differentiation and proliferation showing its critical function in maintaining cellular homeostasis. The protein also participates in hypoxia response being upregulated under low oxygen conditions which points to its adaptability and function under stress.
Pathways
SHARP2/DEC1 is an important component of the circadian clock and hypoxia signaling pathways. It modulates the activity of other clock genes and interacts with the PER and CRY protein families adding precision to circadian regulation. In the hypoxia pathway SHARP2/DEC1 activity affects the expression of genes involved in cellular adaptation to low oxygen levels cooperating with hypoxia-inducible factors to maintain balance during such conditions.
Changes in SHARP2/DEC1 expression link to cancer and metabolic syndromes. Elevated levels of this protein associate with aggressive tumor growth in different cancers highlighting its potential as a biomarker for tumor progression. Moreover SHARP2/DEC1 involvement in metabolic pathways shows its connection to disorders like obesity and diabetes. This protein's interaction with p53 in cancer pathways further portrays its influence on cell survival and apoptosis making it a significant target for therapeutic research.