Abcam, ab70804, Anti-PPM1B antibody

Size: 100µL
Rabbit Polyclonal PPM1B antibody. Suitable for IP, WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human PPM1B aa 450 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PPM1B aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O75688

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PPM1B also known as protein phosphatase 1B is a serine/threonine phosphatase with a molecular mass of approximately 55 kDa. This protein plays an important role in dephosphorylating serine/threonine residues on its target proteins adjusting their functional states. PPM1B is widely expressed in various tissues throughout the body including the heart skeletal muscle and liver. Its activity helps in modulating different signaling pathways by reversing the phosphorylation status of target proteins.
Biological function summary
PPM1B influences diverse cellular processes such as cell cycle regulation and stress response. It is not part of a large complex but interacts with specific substrates to exert its effects. PPM1B can impact apoptosis and cell differentiation through its action on certain substrates. Its regulatory function is important for maintaining cellular homeostasis and adaptation to environmental changes.
Pathways
Multiple signaling cascades demonstrate the involvement of PPM1B. It plays a significant role in the regulation of the p38 MAPK pathway which is important for stress response and inflammatory processes. In this pathway PPM1B interacts with MAPKAPK2 modulating its activity. PPM1B also participates in the TGF-beta signaling pathway where it can affect the phosphorylation status of SMADs. These interactions emphasize PPM1B's regulatory importance in response to extracellular signals.
Alterations in PPM1B activity are linked to cardiovascular and inflammatory conditions. For example changes in its function can contribute to the pathogenesis of hypertension through its effect on the TGF-beta pathway and related proteins like SMAD2. In inflammatory diseases the role of PPM1B in the p38 MAPK pathway shows its connection to proteins such as MAPKAP2 highlighting its potential involvement in inflammatory responses. These connections demonstrate the therapeutic interest in targeting PPM1B for disease treatment and management.