Abcam, ab71163, Anti-ASPP1 antibody

Size: 100µL
Rabbit Polyclonal ASPP1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PPP1R13B.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PPP1R13B. The exact immunogen used to generate this antibody is proprietary information.Q96KQ4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ASPP1 also known as Apoptosis Stimulating Protein of p53 1 functions mechanically as an important regulator of apoptosis and cell growth. It forms part of a family of proteins that interacts with the tumor suppressor protein p53 enhancing its ability to activate apoptosis-related genes. ASPP1 has a molecular mass of approximately 124 kDa and is expressed in various tissues especially in those that demand high regulation of cellular proliferation and survival.
Biological function summary
ASPP1 engages in cellular processes by playing an important role in promoting p53-dependent apoptosis. It does this by binding to p53 and increasing its binding to specific promoters of apoptotic genes. ASPP1 can integrate into protein complexes that modulate cell cycle arrest and apoptosis. The activity of ASPP1 not only leads to the activation of pro-apoptotic genes but also suppresses those involved in cell survival ensuring proper regulation of cell fate decisions.
Pathways
ASPP1 is a pivotal player in the p53 signaling pathway a central pathway that regulates apoptosis and cell cycle. ASPP1 enhances p53's transcriptional activity on target genes such as bax and p21 which are critical components involved in apoptotic and cell cycle pathways. Moreover ASPP1 interacts with proteins like ASPP2 and iASPP that belong to the same protein family influencing common cellular responses and signaling mechanisms.
ASPP1 connects to cancer and neurodegenerative diseases. Its interactions with p53 suggest a significant role in tumor suppression where downregulation or mutations of ASPP1 can contribute to tumorigenesis. Additionally altered expression of ASPP1 can affect neurodegenerative diseases by disrupting normal apoptotic processes. As part of these disease contexts ASPP1’s relationship with p53 amplifies its tumor-suppressing capabilities while also potentially impacting neurological health.