Abcam, ab71786, Anti-MAGEA2 antibody - Aminoterminal end

Size: 400µL
Rabbit Polyclonal MAGEA2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MAGEA2 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MAGEA2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P43356

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS., Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MAGEA2 also known as Melanoma-associated antigen A2 is a member of the MAGE gene family located on the X chromosome. This protein has a mass of approximately 35 kDa. MAGEA2 expresses in a wide range of cancers and is usually absent in normal tissues except in the testis and placenta. This makes it a significant target for cancer research particularly in developing cancer vaccines and immunotherapies.
Biological function summary
MAGEA2 plays a role in regulating the p53 tumor suppressor pathway. It interacts with other proteins to inhibit p53 activity impacting cell cycle control and apoptosis. MAGEA2 is not generally part of a larger macromolecular complex but it can interact with several proteins that modulate its effects on cellular processes.
Pathways
Focusing on cell cycle and apoptosis reveals that MAGEA2 participates in inhibiting the p53 pathway. This suppression helps cancer cells evade normal growth control mechanisms. In addition to p53 MAGEA2 associates with proteins such as HDAC3 involved in transcriptional regulation. These interactions make it an intriguing target for modulating key pathways involved in cell proliferation and survival.
MAGEA2 shows strong associations with various cancers including melanoma and lung cancer. Its ability to suppress p53 activity connects it to the pathogenesis of these diseases where normal p53 function is often compromised. MAGEA2's interaction with proteins like HDAC3 also implies that targeting this network can potentially reverse aberrant epigenetic modifications seen in these cancers offering a therapeutic avenue.