Abcam, ab72056, Anti-KAT8 / MYST1 / MOF antibody

Size: 100µL
Rabbit Polyclonal KAT8 / MYST1 / MOF antibody. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human KAT8 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human KAT8 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9H7Z6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The KAT8 protein also known as MYST1 or MOF functions as a histone acetyltransferase. It acetylates histone H4 at lysine 16 which is critical for chromatin structure and gene expression regulation. The molecular mass of KAT8 is approximately 55 kDa. This protein shows high expression in testis and is also present in other tissues. KAT8 is part of the MYST family of acetyltransferases sharing similarities with other MYST family proteins such as MOF protein.
Biological function summary
KAT8 plays an essential role in gene transcription regulation by forming part of a complex known as the MSL (Male-Specific Lethal) complex. This complex ensures dosage compensation in Drosophila by adjusting gene expression levels. KAT8 is vital for the maintenance of chromatin structure influencing gene activation and silencing across various biological systems. It interacts with several co-factors during transcription regulation further highlighting its functional significance in the epigenetic landscape.
Pathways
KAT8 engages in processes linked to chromatin modification and gene expression. Specifically it plays a significant role in the pathways of chromatin organization and transcriptional regulation by RNA polymerase II. The protein ENL participates in related pathways and interacts with KAT8 during transcription elongation. These interactions highlight KAT8's role in epigenetic regulation affecting multiple genes' transcription states.
KAT8 is associated with cancers and neurodevelopmental disorders. Aberrant expression or mutations in KAT8 have been observed in certain cancers making it a potential target for therapeutic intervention. In neurodevelopmental disorders changes in KAT8 acetyltransferase activity affect neuronal gene expression implicating it in disorders linked to cognitive deficits. Another protein TIP60 shows functional overlap with KAT8 in these conditions suggesting interconnected roles in disease pathogenesis.