Abcam, ab72230, Anti-PGC1 alpha + beta antibody

Size: 100µg
Rabbit Polyclonal PGC1 alpha antibody. Suitable for ELISA, WB, ICC/IF and reacts with Synthetic peptide - Human, Mouse, Rat, Human samples. Cited in 52 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ELISA, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:The immunogen design for ab72230 is shown to cross-react with both PGC1 alpha (ID: 124782 and Swissprot Q9UBK2) and PGC1 beta (ID: 240776 and SwissProt Q86YN6). From Jan 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help. You may also be interested in our alternative recombinant antibody, ab188102.

Product details:
PGC1 alpha has a predicted MW of 92 kDa and PGC1 beta has a predicted MW of 113 kDa.
This product may be covered by one or more of the following U.S. Patents.
6,166,192
6,426,411
6,525,178
6,872,391
6,908,987
7,250,283
7,091,006
7,354,738
8,105,774
8,445,233

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PGC1 alpha and beta also known as Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha (PGC-1α) and 1-beta (PGC-1β) are transcriptional coactivators with molecular weights of approximately 91 kDa and 102 kDa respectively. These proteins are important in regulating energy metabolism and are highly expressed in tissues with high energy demand such as skeletal muscle heart and brown adipose tissue. The proteins interact with nuclear hormone receptors and various transcription factors to control the expression of genes involved in energy homeostasis.
Biological function summary
PGC1 alpha and beta activate and coordinate the expression of genes involved in mitochondrial biogenesis and oxidative phosphorylation. They do not form a complex themselves but work with other transcriptional regulators to enhance gene expression. These proteins influence the metabolic processes of cells regulating the conversion of energy substrates into usable cellular energy. They are critical in adapting to different physiological conditions like exercise and fasting by modulating the capacity for energy production.
Pathways
PGC1 alpha and beta integrate signals from various pathways like the PPAR and AMPK pathways which are significant for energy balance and metabolism. PGC1 alpha particularly interacts with proteins such as NRF1 and NRF2 to promote mitochondrial function. Through these pathways PGC1 coactivators help regulate metabolism by altering the transcriptional activity of genes involved in energy expenditure and metabolic adaptation.
PGC1 alpha and beta have significant implications in conditions such as obesity and diabetes. Dysregulation of these proteins affects the balance of energy metabolism leading to metabolic disorders. PGC1 alpha in particular interacts with proteins like SIRT1 which influence insulin sensitivity and metabolic rate thereby playing a role in the development and progression of these diseases. The modulation of PGC1 activity has potential therapeutic implications for managing metabolic disorders.