Abcam, ab72237, Anti-RBM25 antibody

Size: 100µL
Rabbit Polyclonal RBM25 antibody. Suitable for IHC-P, IP, WB and reacts with Mouse, Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human RBM25.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RBM25. The exact immunogen used to generate this antibody is proprietary information.P49756

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was affinity purified using an epitope specific to BTAF1 immobilized on solid support, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RBM25 also known as RNA-binding motif protein 25 plays a significant role in RNA splicing mechanisms. This protein has a mass of approximately 97 kDa. It localizes in the nucleus and is widely expressed in various tissues including the heart brain and placenta. RBM25 contains an RNA recognition motif that binds to specific RNA sequences influencing the processing of pre-mRNA into mature mRNA.
Biological function summary
RBM25 mediates alternative splicing a process important for generating diverse protein isoforms from a single gene. It acts as part of the spliceosomal complex and interacts with other splicing factors to modulate exon inclusion or exclusion. Through its regulatory role RBM25 influences gene expression patterns and contributes to the maintenance of cellular homeostasis. Its function is vital in tissues where precise regulation of splicing is necessary.
Pathways
RBM25 is actively involved in splicing regulation within the context of gene expression. It participates in the mRNA processing gene expression pathway while interacting with proteins like SF3B1 and U2AF2 which also play significant roles in the spliceosome. These interactions help fine-tune the splicing process facilitating the production of functional mRNAs that encode necessary proteins for various cellular processes.
RBM25 is associated with cardiovascular diseases and certain cancers. Abnormalities in the splicing function it regulates can lead to incorrect mRNA isoform production contributing to disease pathogenesis. For example it modulates splicing events linked to apoptosis-related genes interacting with other splicing factors like hnRNPL therefore potentially influencing cancer progression. Understanding its association with these diseases can open avenues for targeted therapeutic strategies.