Abcam, ab72462, Recombinant Human Tau410 protein

Size: 20µg / 50µg
Recombinant Human Tau410 protein is a Human Full Length protein, in the 1 to 410 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, WB.
Key facts
Purity:>90% Densitometry,
Expression system:Escherichia coli,
Tags:Tag free,
Applications:SDS-PAGE, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P10636,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.00385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.00174% PMSF

Product details:
This protein is full-length isoform 5, Isoform Tau-C.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tau410 also known as Big Tau is a form of the microtubule-associated protein Tau. It has a molecular mass of approximately 48 kDa. Unlike other Tau isoforms Tau410 is expressed predominantly in neuronal tissues including the central nervous system. This isoform serves important functions in stabilizing microtubules which are fundamental for cell shape intracellular transport and signaling within neurons.
Biological function summary
Tau410 plays a significant role in maintaining the stability of nerve cell architecture. It interacts with tubulin to promote assembly and stability of microtubules. While not commonly forming part of an extensive complex like other isoforms Tau410's primary interaction is with microtubules. It is essential for neuronal cell functions and mechanisms such as axonal transport which is important for transmitting signals across neurons.
Pathways
Tau410 integrates into cellular mechanisms that control cytoskeleton dynamics. It plays an important role in the microtubule organization pathway impacting both the polymerization and depolymerization actions within cells. Furthermore Tau410 links with kinases such as GSK-3β which phosphorylate Tau and affect its binding affinity to microtubules. This interaction integrates Tau410 into signaling pathways that influence neuron function and health.
Tau410 shows a strong connection with neurodegenerative conditions particularly Alzheimer's disease. Misregulation or abnormal phosphorylation of Tau proteins including Tau410 leads to the formation of neurofibrillary tangles a hallmark of Alzheimer's pathology. Furthermore Tau410 interacts with amyloid precursor protein (APP) linking it to the aggregation of beta-amyloid plaques another key feature of Alzheimer's disease. Understanding Tau410's role offers potential insights into therapeutic targets for neurodegenerative disorders.