Abcam, ab73055, Anti-A3H antibody

Size: 50µg
Mouse Polyclonal A3H antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human APOBEC3H.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human APOBEC3H.Q6NTF7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: Whole serum, 0.812% Sodium chloride, 0.1136% Disodium hydrogenorthophosphate, 0.0225% Potassium chloride, 0.0204% Potassium phosphate monobasic, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
A3H also known as APOBEC3H is a member of the apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) family. The protein has a molecular mass of approximately 23 kDa. A3H is mainly expressed in immune-related tissues such as lymph nodes and spleen and plays a role in the innate immune response. It functions as a cytidine deaminase converting cytidine to uridine in single-stranded DNA which can lead to mutations in viral genomes.
Biological function summary
A3H plays a role in the defense against viral pathogens by editing viral genomes and inhibiting their replication. A3H exists as part of a cellular defense complex that acts against retroviruses such as HIV-1. By inducing hypermutation A3H restricts viral replication and spread. Among the APOBEC3 family members A3H shows unique substrate specificity and activity profiles contributing to the diversity of the host antiviral response.
Pathways
A3H integrates into the broader context of innate immune pathways including interferon signaling. In these pathways A3H serves as a critical effector in innate viral immunity complementing the action of other APOBEC3 family members like APOBEC3G. These proteins work together to inhibit the replication of retroviruses through distinct yet overlapping pathways contributing to a robust antiviral state within host cells.
A3H links to HIV-1 pathogenesis and can influence disease progression. It plays a pivotal role in restricting HIV-1 by incorporating itself into viral particles and inducing detrimental mutations. This activity can affect HIV-1 resistance to therapy. Other APOBEC proteins such as APOBEC3G also participate in this process reflecting a coordinated response that counters HIV-1 infection and affects virus-host interactions. Understanding A3H functions and interactions contributes to better insights into viral pathogenesis and potential therapeutic targets.