Abcam, ab73331, Anti-DeltaD antibody [Dld 5C7/2, zdd2]

Size: 50µg
Mouse Monoclonal DeltaD antibody. Suitable for Flow Cyt, ELISA, WB, ICC/IF, IHC - Wmt, IHC-Fr and reacts with Zebrafish samples. Cited in 12 publications. Immunogen corresponding to Native Full Length Protein corresponding to Zebrafish dld.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:Dld 5C7/2, zdd2,
Isotype:IgG1,
Carrier free:No,
Reacts with:Zebrafish,
Applications:Flow Cyt, IHC - Wmt, ELISA, WB, ICC/IF, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Zebrafish dld.Q8UWJ4,
Epitope:Zebrafish DeltaD protein extracellular domain.,
Specificity:This antibody recognises the extracellular domain of zebrafish DeltaD. This antibody does not detect DeltaC; but it cross-reacts weakly with DeltaA.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.02% Sodium azideConstituents: 99.98% PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DeltaD also known as Notch ligand Delta-like 3 is a member of the Delta/Notch family. It has a molecular mass of approximately 60 kDa. Expression of DeltaD occurs mainly in human embryonic tissues though it is also present in some adult tissues including brain and muscle. The Notch signaling pathway where DeltaD functions as a ligand is essential for communication between adjacent cells via binding with Notch receptors.
Biological function summary
Proteins from the Delta/Notch family influence numerous developmental processes. DeltaD participates in the regulation of cell fate determination and differentiation during embryonic development. It works within the Notch signaling pathway where it forms a complex with Notch receptors and other ligands to control the transcription of target genes. The modulation of Notch signaling by DeltaD is important for proper tissue patterning and morphogenesis.
Pathways
Many cellular activities rely on DeltaD's interaction with the Notch signaling pathway. This pathway influences critical processes such as angiogenesis and neurogenesis. Within these framework DeltaD interacts with several Notch receptors such as Notch1 and Notch2 to regulate gene expression. The interplay between DeltaD and these receptors ensures the correct execution of developmental programs and cellular differentiation.
Dysregulation of DeltaD expression associates with congenital conditions such as spondylocostal dysostosis and neural tube defects. Anomalies in the Notch signaling pathway where DeltaD acts can disrupt normal development resulting in such pathologies. Notch1 and other family members are involved in the pathophysiology of these disorders emphasizing DeltaD's role in maintaining proper developmental signaling and tissue function.