Abcam, ab73336, Anti-DeltaC antibody [zdc2]

Size: 50µg
Mouse Monoclonal DeltaC antibody. Suitable for Flow Cyt, ELISA, WB, ICC/IF, IHC - Wmt, IHC-Fr and reacts with Zebrafish samples. Cited in 5 publications. Immunogen corresponding to Native Full Length Protein corresponding to Zebrafish Delta-like protein C.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:zdc2,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Zebrafish,
Applications:ICC/IF, Flow Cyt, IHC - Wmt, ELISA, IHC-Fr, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Zebrafish Delta-like protein C.Q9IAT6,
Epitope:DeltaC extracellular domain.,
Specificity:Delta proteins activate Notch through a binding reaction that depends on their extracellular domains. During somitogenesis, Notch signalling via DeltaC keeps the oscillations of neighbouring cells in synchrony. DeltaC is also expressed in subsets of cells in the nervous system and elsewhere.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The DeltaC protein sometimes referred to as dlC is a member of the Delta family part of the Notch signaling pathway. Its molecular mass is approximately 26 kDa. Expression of DeltaC occurs predominantly in the central nervous system and various embryonic tissues where it plays a role in cell fate determination. The protein functions through interactions with the Notch receptors transmitting signals essential for tissue development and differentiation.
Biological function summary
DeltaC mediates cell-to-cell communication that informs the differentiation of cells within tissues. It forms part of the ligand-receptor complex where DeltaC acts as a ligand binding to Notch receptors on adjacent cells. This interaction triggers a proteolytic cleavage of the Notch receptor activating the Notch signaling pathway. This process influences the transcription of target genes necessary for the developmental patterning in organisms.
Pathways
DeltaC acts as a critical factor in the Notch signaling pathway. This pathway regulates several processes like neurogenesis and somitogenesis. DeltaC interacts with proteins such as Jagged which is another ligand involved in Notch signaling. These interactions modulate cellular processes by influencing gene expression patterns essential for developmental milestones and homeostasis.
Mutations or dysregulation of DeltaC have been implicated in certain cancers including neuroblastoma due to its role in cell differentiation and tissue patterning. Additionally alterations in DeltaC expression link to Alagille syndrome a genetic disorder affecting the liver and other organs. The DeltaC-related aberrations influence Notch receptor interactions especially co-involving Jagged proteins critical in these pathophysiological states.