Abcam, ab74138, Anti-NDUFA4L2 antibody

Size: 100µg
Rabbit Polyclonal NDUFA4L2 antibody. Suitable for ELISA, WB and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2. The exact immunogen used to generate this antibody is proprietary information.Q9NRX3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NDUFA4L2 also known as NADH dehydrogenase [ubiquinone] 1 alpha subcomplex 4-like 2 plays a role in cellular respiration. This protein weighs approximately 14 kDa and locates mainly in the inner mitochondrial membrane. It shows enhanced expression in hypoxic conditions facilitating adaptation to low oxygen environments. NDUFA4L2 exhibits tissue-specific expression particularly in organs that experience variable oxygen levels such as the lungs and heart.
Biological function summary
NDUFA4L2 modulates the activity of the mitochondrial electron transport chain. It is an important component of complex I (NADH:ubiquinone oxidoreductase) which is essential for efficient ATP generation through oxidative phosphorylation. By fine-tuning electron transfer and reducing excessive reactive oxygen species production NDUFA4L2 contributes to cellular energy homeostasis and protection against oxidative stress.
Pathways
NDUFA4L2 plays a role in cellular energy metabolism and the hypoxia response pathway. It interacts closely with other components of the electron transport chain notably NDUFV1 and NDUFS1 to support cellular respiration and adaptation during oxygen-limited conditions. Through these pathways NDUFA4L2 ensures cells maintain energy production while minimizing oxidative damage.
Altered expression of NDUFA4L2 has links to cancer and ischemic diseases. Overexpression often appears in tumors contributing to the metabolic switch toward aerobic glycolysis known as the Warburg effect. In ischemic conditions NDUFA4L2 may help to reduce tissue damage by limiting oxidative stress. Understanding NDUFA4L2's role alongside proteins like HIF-1α which regulates its expression could offer insights into therapeutic targets for these conditions.