Abcam, ab7463, Anti-Laminin 1+2 antibody

Size: 100µL
Anti-Laminin 1+2 antibody (ab7463) is a rabbit polyclonal antibody detecting Laminin 1+2 in Western Blot, IHC-P, ICC/IF . Suitable for Human, Mouse, Rat . - Over 60 publications - Trusted since 2002
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Mouse Lama1.P19137,
Specificity:This antibody is pan-specific and reacts well with all laminin isoforms tested: laminin-1 (alpha-1, beta-1, and gamma-1) and laminin-2 (alpha-2, beta-1, and gamma-1).

Product details:
What is this antibody validated in?
Anti-Laminin 1+2 antibody (ab7463) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples.
Trusted by the scientific community
Anti-Laminin 1+2 (ab7463) was first used in a scientific publication in 2002 and has been cited over 60 times in peer-reviewed journals.
Reviewed by scientists
Anti-Laminin 1+2 (ab7463) has over 5 independent reviews from customers.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.05% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Laminin 1+2 known also as laminin-1 and laminin is an important component of the extracellular matrix. It consists of alpha beta and gamma chains which together form a large complex with a mass of around 800 kDa. Laminin 1+2 is expressed in various tissues particularly in basement membranes of epithelial and endothelial cells. This complex structure contributes to a wide range of mechanical roles such as structural support and cell adhesion.
Biological function summary
Laminin 1+2 serves as an important mediator in cell differentiation migration and survival. It acts as a part of the basement membrane complex where it works together with other proteins like collagen IV and nidogen. This interaction promotes a stable extracellular matrix facilitating communication between cells and affecting processes essential for tissue maintenance and repair.
Pathways
Laminin 1+2 actively participates in pathways like the integrin and MAPK signaling pathways. These pathways are important for cellular responses to environmental signals. Laminin 1+2 interacts with integrin receptors mediating communication between the extracellular matrix and the cytoskeleton. This interaction helps regulate cell shape and movement. In the MAPK pathway it influences signal transduction that affects gene expression and cellular functions.
Laminin 1+2 is linked to muscular dystrophies and certain forms of cancer. Muscular dystrophy often involves mutations in proteins associated with laminins such as dystroglycan disrupting the stability of muscle cell membranes. In cancer abnormal laminin expression can promote tumor progression by altering cell adhesion properties. Understanding laminin's role in these conditions provides insights into potential therapeutic targets.