Abcam, ab75008, Anti-ClC-4 antibody

Size: 100µg
Rabbit Polyclonal ClC-4 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CLCN4.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CLCN4. The exact immunogen used to generate this antibody is proprietary information.P51793

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ClC-4 also known as chloride channel 4 represents a member of the chloride channel family. It functions as an anion transporter facilitating the movement of chloride ions across cellular membranes. ClC-4 is expressed in various tissues including the kidney brain and skeletal muscle. The protein has a molecular weight of around 91 kDa and is encoded by the CLCN4 gene. Through its transmembrane domain operations ClC-4 helps maintain ion homeostasis and cell volume regulation.
Biological function summary
The functions of ClC-4 involve ion exchange activities important for cellular operations. It does not act alone but is part of a larger complex in particular cell types. In neuronal tissues ClC-4 contributes to the modulation of synaptic transmission and neuronal excitability. Its activity affects the electrochemical gradient across cell membranes essential for normal cellular signaling and metabolism.
Pathways
ClC-4 plays a role in regulating systemic chloride homeostasis and acid-base balance. It functions within pathways related to cell signaling and volume regulation. ClC-4 connects to pathways involving other chloride channels such as ClC-3 and ClC-5 which share complementary roles in ion transport and cellular function. This integration helps maintain the overall balance of ionic and pH levels within the body.
Mutations or dysfunctions in ClC-4 link to neurological conditions like X-linked mental retardation and epilepsy. Such diseases suggest that disruptions in chloride ion transport involve broader neural networking issues. ClC-4's involvement in these disorders intersects with proteins such as ClC-3 which also engages in maintaining neuronal chloride homeostasis. Understanding ClC-4 can provide insights into the pathophysiology of these conditions.