Abcam, ab75148, Anti-B1R antibody

Size: 100µg
Rabbit Polyclonal B1R antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human BDKRB1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human BDKRB1. The exact immunogen used to generate this antibody is proprietary information.P46663

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The B1R also known as B1 kinin receptor is a G protein-coupled receptor involved in the pro-inflammatory response. It has a mass of around 41 kDa and often occurs in low expression under normal physiological conditions. However the expression increases significantly during tissue injury and inflammation. B1R is predominantly expressed in various tissues including vascular endothelial cells smooth muscle and certain immune cells. Its upregulation in inflamed or injured tissues makes it a significant target for therapeutic interventions.
Biological function summary
B1R mediates cellular responses to kinins particularly bradykinin-related peptides that form during inflammation or injury. This receptor does not typically appear as part of a complex acting instead as a stand-alone mediator that influences pain transmission vasodilation and leukocyte recruitment. By engaging with specific ligands B1R contributes to the induction of pro-inflammatory pathways and signals eventual tissue repair.
Pathways
B1R plays an important role in the kinin-kallikrein system and is vital for inflammatory responses. This system includes interactions with kinins such as bradykinin which activates B1R leading to the activation of signaling molecules like protein kinase C (PKC) and phospholipase C (PLC). These kinases further impact various downstream effects including the activation of nuclear factor-kB (NF-kB) that enhance inflammatory responses positioning B1R within broader vascular and inflammatory pathways.
B1R has been associated with inflammatory diseases such as rheumatoid arthritis and diabetic complications. The receptor’s interaction with proteins like NF-kB facilitates inflammation and exacerbates disease progression in these contexts. B1R overexpression can promote chronic inflammation and tissue damage making it a potential target for therapeutic strategies in inflammatory and pain-related disorders seeking to mitigate symptoms by disrupting its pro-inflammatory role.