Abcam, ab75285, Anti-OPN3 antibody

Size: 100µg
Rabbit Polyclonal OPN3 antibody. Suitable for ELISA, WB, ICC/IF and reacts with Mouse, Human samples. Cited in 19 publications. Immunogen corresponding to Synthetic Peptide within Human OPN3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IF, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human OPN3. The exact immunogen used to generate this antibody is proprietary information.Q9H1Y3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-The antibody was affinity purified from rabbit antiserum by affinity chromatography, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OPN3 also known as Opsin 3 or encephalopsin is a protein that functions mechanically as a part of the G protein-coupled receptor (GPCR) family which are involved in signal transduction. This protein has an approximate mass of 39 kDa. Research shows OPN3 expression in various human tissues such as the brain and liver indicating its diverse roles throughout the body.
Biological function summary
OPN3 plays a role in several physiological processes beyond its classical function in photoreception. While not a part of a larger complex it modulates different signaling pathways influencing cellular responses to environmental changes. Such actions make OPN3 a point of interest for understanding its function in non-visual opsin behaviors.
Pathways
OPN3 links to important biological processes like circadian rhythm regulation and cellular responses to light. It interacts with signaling proteins like G-proteins which help mediate its effects in these pathways. This connection suggests its involvement in mechanisms similar to other light-sensitive proteins.
OPN3 shows a relation to conditions such as seasonal affective disorder and other mood-related disorders. Research points to OPN3's impact on circadian-related symptoms where proteins similar to OPN3 such as melanopsin also play roles. This suggests potential therapeutic implications for OPN3 in managing these conditions.