Abcam, ab75312, Anti-GPCR GPR119 antibody

Size: 100µg
Rabbit Polyclonal GPCR GPR119 antibody. Suitable for ELISA, WB, IHC-P, ICC/IF, IHC-Fr and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human GPR119 aa 200-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:ELISA, IHC-P, WB, ICC/IF, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GPR119 aa 200-250. The exact immunogen used to generate this antibody is proprietary information.Q8TDV5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPR119 also known as Glucose-dependent insulinotropic receptor is a G protein-coupled receptor (GPCR) that plays an essential role in metabolic regulation. With a mass of approximately 51 kDa it is expressed mainly in pancreatic beta cells and intestinal enteroendocrine cells. This receptor senses dietary lipids and promotes insulin secretion in response to meals. It also couples with G proteins to initiate intracellular signaling cascades important for energy homeostasis.
Biological function summary
GPR119 functions as a sensor of lipid-derived molecules often acting as an aryl agonist receptor. It is not part of a larger complex but can activate a series of downstream pathways upon ligand binding. When activated by endogenous and synthetic agonists GPR119 stimulates the release of incretin hormones such as GLP-1 and GIP. This hormone release enhances insulin response and promotes optimal glycemic control essential in maintaining blood glucose levels.
Pathways
GPR119 signaling pathway is integral in glucose metabolism and energy balance. It links to both the incretin hormone signaling pathway and the insulin signaling pathway. Upon activation it influences the levels of cAMP an important secondary messenger that modulates several downstream effects including the regulation of the insulin receptor. GPR119 interacts with other proteins such as adenylate cyclase affecting insulin secretion and lipid metabolism.
GPR119 has significant relevance to type 2 diabetes and obesity. Its role in glucose homeostasis and energy balance makes it a potential therapeutic target for these conditions. Researchers examine GPR119 agonists as possible treatments for enhancing insulin secretion and controlling body weight. The receptor is linked to related pathways integrating multiple metabolic signals including those mediated by GLP-1 an important hormone involved in energy regulation and glycemic control.