Abcam, ab76020, Anti-Sodium Potassium ATPase antibody [EP1845Y] - Plasma Membrane Loading Control

Size: 20µL / 100µL / 250µL / 1mL
Anti-Sodium Potassium ATPase antibody [EP1845Y] - Plasma Membrane Loading Control (ab76020) is a rabbit monoclonal antibody detecting Sodium Potassium ATPase in Western Blot, Flow Cytometry, IHC-P, ICC/IF . Suitable for Chinese hamster, Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 290 publications - Trusted since 2009
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP1845Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human, Chinese hamster,
Applications:WB, ICC/IF, Flow Cyt (Intra), IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody recognizes an intracellular epitope of Sodium/potassium-transporting ATPase alpha-1 subunit.

Product details:
Anti-Sodium Potassium ATPase antibody [EP1845Y] - Plasma Membrane Loading Control (ab76020) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P and WB.
Anti-Sodium Potassium ATPase antibody [EP1845Y] - Plasma Membrane Loading Control (ab76020) was first used in a scientific publication in 2009 and has been cited over 291 times in peer reviewed journals. It's performance in Western Blot in human and mouse samples is trusted by the scientific community.
Abcam's high quality manufacturing and validation processes ensure Anti-Sodium Potassium ATPase antibody [EP1845Y] - Plasma Membrane Loading Control (ab76020) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
Anti-Sodium Potassium ATPase antibody [EP1845Y] - Plasma Membrane Loading Control (ab76020) has 18 independent reviews from customers.
Anti-Sodium Potassium ATPase antibody [EP1845Y] - Plasma Membrane Loading Control (ab76020) specifically detects Sodium Potassium ATPase (UniProt ID: P05023; Molecular weight: 113kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL, 250 µL and 1 mL).
Conjugation-ready, carrier free format available for antibody clone EP1845Y -
ab167390
Antibody clone EP1845Y is also available pre-conjugated to a variety of labels for your convenience - HRP, Alexa Fluor
488, Biotin, Alexa Fluor
647, PE, Alexa Fluor
405, Alexa Fluor
555, APC (
ab185065
ab197713
ab198366
ab198367
ab209299
ab210143
ab274883
ab314288
Top cited antibody on the market with >384 citations. Sodium Potassium ATPase is essential for studying ion transport and cellular homeostasis, aiding research on nerve function, muscle contraction and various physiological processes
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Na/K-ATPase also known as the sodium-potassium pump or Na K ATPase pump is a transmembrane protein responsible for maintaining the electrochemical gradient across the plasma membrane. The protein actively transports three sodium ions out of the cell and two potassium ions in which helps generate the resting membrane potential. It comprises an alpha catalytic subunit which has a molecular weight of around 112 kDa to 114 kDa and a beta subunit. Na/K-ATPase is widely expressed across many tissues with high concentrations in nerve cells muscle tissues and epithelial cells.
Biological function summary
The sodium-potassium pump is vital in maintaining cellular homeostasis. It plays a significant role in regulating cell volume controlling the ion balance within cells and enabling proper function of nerve and muscle cells. Na/K-ATPase forms part of a larger transport complex working closely with other ion pumps and exchangers to sustain cellular conditions. This activity ensures that cells respond and adapt to various physiological changes.
Pathways
The Na/K-ATPase functions integrally in cellular signaling and metabolic pathways. It interfaces with the Ras-associated protein 1 (Rap1) pathway which influences cell adhesion and growth. Furthermore Na/K-ATPase is linked to the renin-angiotensin system which modulates blood pressure and fluid balance through its interaction with angiotensin receptors. Through these associations Na/K-ATPase not only maintains cellular environments but also influences systemic physiological processes.
Na/K-ATPase malfunctions have connections to conditions like congestive heart failure and certain neurological disorders. Altered activity in the sodium-potassium pump disrupts ion gradients affecting cardiac and neuronal functions. Additionally Na/K-ATPase interacts with the caveolin proteins in cardiovascular diseases where their dysregulation contributes to disease pathogenesis. Understanding and targeting Na/K-ATPase could provide insights into therapeutic strategies for these conditions.