Abcam, ab76217, Anti-GPCR GPR35 antibody

Size: 100µg
Rabbit Polyclonal GPCR GPR35 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPR35 also known as G protein-coupled receptor 35 is a membrane-bound protein with a mass of approximately 35 kDa. It belongs to the GPCR family which is involved in transducing extracellular signals into cellular responses. This receptor is expressed in various tissues including the gastrointestinal tract immune system and certain regions of the central nervous system. Its structure typically features the characteristic seven-transmembrane domain configuration typical of GPCRs with complex cytoplasmic regions or domains vital for signal transduction.
Biological function summary
GPR35 influences several cellular responses and plays a role in regulating immune and inflammatory processes. It often functions in conjunction with other proteins as part of larger receptor complexes that modulate physiological reactions. In immune cells particularly leukocytes it contributes to cytokine release and cellular migration. In the gastrointestinal system GPR35 impacts intestinal homeostasis and barrier integrity highlighting its importance in maintaining normal physiological function.
Pathways
GPR35 participates in key signaling pathways including the G protein and beta-arrestin pathways. These pathways are integral to signal transduction mechanisms which influence cellular responses. GPR35 signaling pathway links it with proteins such as G proteins and beta-arrestins which facilitate diverse intracellular signaling cascades. These interactions orchestrate responses to various physiological and pathological stimuli by modulating downstream signaling networks.
GPR35 has been implicated in inflammatory bowel diseases and certain metabolic disorders. Evidence suggests its involvement in conditions such as ulcerative colitis where dysregulation of immune responses is pivotal. The receptor's interaction with proteins such as beta-arrestins in these contexts can exacerbate or ameliorate pathological states linking GPR35 to therapeutic strategies targeting inflammation. Another disease associated with GPR35 is diabetes where its modulation of metabolic pathways might influence disease progression.