Abcam, ab76243, Anti-CTNNBL1 antibody [EP2669Y]

Size: 100µL / 1mL
Rabbit Monoclonal CTNNBL1 antibody. Suitable for IHC-P, WB, ICC/IF, Flow Cyt and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP2669Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, Flow Cyt, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
This product has switched from a hybridoma to recombinant production method on 18th September 2023
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CTNNBL1 also known as Catenin beta-like protein 1 is a protein involved in cellular processes with a molecular mass of approximately 62 kDa. The protein shows a wide expression pattern across various tissues including the heart liver and kidney but it is especially present in the nucleus and cytoplasm of cells. CTNNBL1 belongs to the armadillo/beta-catenin family which implies a role in intracellular signaling and structural functions within cells.
Biological function summary
CTNNBL1 plays a role in mRNA processing and the regulation of gene expression. It is a component of the spliceosomal complex which is essential in the process of splicing precursor mRNA into mature mRNA. This indicates its involvement in the control of mRNA stability and accurate gene expression. By participating in these molecular processes CTNNBL1 contributes to efficient protein synthesis and cellular regulation.
Pathways
CTNNBL1 influences several signaling cascades notably its role in the Wnt signaling and RNA splicing pathways. In the Wnt signaling pathway CTNNBL1 interacts with other proteins such as beta-catenin to regulate gene transcription related to cell proliferation and differentiation. Furthermore its involvement in the spliceosomal pathway connects it with proteins essential in mRNA splicing including components like small nuclear ribonucleoproteins.
CTNNBL1 has been associated with conditions such as cancer and neurodegenerative disorders. Its interaction with beta-catenin and the Wnt pathway suggests a potential role in tumorigenesis given the pathway's importance in cell proliferation and survival. Additionally disruptions in RNA splicing and processing can link CTNNBL1 to neurological conditions where precise gene regulation is critical. These associations indicate its possible involvement in both promoting abnormal cell growth and contributing to neural dysfunction.