Abcam, ab76247, Anti-Ezrin (pThr567)/ Radixin (pThr564)/ Moesin (pThr558) antibody [EP2122Y]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Ezrin phospho T567 antibody. Suitable for IHC-P, Dot, WB and reacts with Mouse, Rat, Human, Synthetic peptide samples. Cited in 15 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP2122Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:IHC-P, WB, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:ab76247 will detect Ezrin, Radixin and Moesin. This antibody detects the phosphorylated target and not the non-phosphorylated epitope.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ezrin radixin and moesin are referred to collectively as the ERM proteins. These proteins mechanically link the actin cytoskeleton to the plasma membrane helping to maintain cell shape and surface structure. Ezrin is often identified with a mass of approximately 82 kDa. ERM proteins are expressed in various tissues such as epithelial cells where they influence cellular morphology and dynamics.
Biological function summary
ERM proteins play a role in signal transduction maintaining cellular architecture and modulating membrane dynamics. As a part of the ERM complex they regulate cytoskeletal rearrangements which are necessary during cellular processes like migration and adhesion. These functions are critical for maintaining cell stability and interaction with the extracellular environment.
Pathways
ERM proteins influence a number of signaling cascades including the PI3K/Akt pathway and the Rho GTPase signaling pathway. These pathways are integral to cell survival proliferation and movement. Through these pathways ERM proteins interact with related proteins such as RhoA and PTEN thereby influencing cellular responses to external stimuli.
ERM proteins have connections to cancer metastasis and neurodegenerative diseases. In cancer altered ERM expression levels can affect tumor progression and metastasis with interactions involving proteins like CD44. In neurodegenerative conditions changes in the regulation of ERM proteins might impact cell survival and tissue integrity. Understanding these relationships helps in developing targeted therapies for managing these diseases.