Abcam, ab76327, Anti-MPZL3 antibody

Size: 50µg
Mouse Polyclonal MPZL3 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MPZL3.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human MPZL3.Q6UWV2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MPZL3 also known as Myelin Protein Zero-Like 3 is a significant transmembrane glycoprotein. The molecular weight of MPZL3 is approximately 34 kDa. It is expressed in various tissues with prominent levels in the skin and hair follicles. The protein contains an Ig-like domain which is essential for its interaction with other cell surface proteins mediating cellular adhesion processes.
Biological function summary
The function of MPZL3 involves cell-cell adhesion and differentiation. MPZL3 plays an essential role in maintaining the structural integrity of tissues where it is expressed. Evidence suggests it forms part of larger protein complexes on the cell membrane enabling important signaling pathways. Its expression contributes significantly to the regulation of epidermal homeostasis and possibly keratinocyte maturation integrating external adhesive signals to cellular responses.
Pathways
MPZL3 interacts within the integrin signaling pathway and might influence the epidermal growth factor receptor (EGFR) pathway. These pathways are integral for cellular adhesion migration and proliferation. MPZL3's role aligns with other adhesion-related proteins like integrins and cadherins interacting to modulate cellular responses to the extracellular environment and mediate various intracellular signaling cascades.
MPZL3's misregulation or mutation links to conditions like ichthyosis and potentially scarring alopecia. These disorders highlight the protein's importance in skin differentiation and hair follicle regulation. MPZL3 possibly interacts with proteins like filaggrin in ichthyosis emphasizing its role in maintaining normal skin barrier function. Understanding MPZL3’s interaction network provides insight into the molecular basis of these conditions and potential therapeutic targets.