Abcam, ab7671, Anti-alpha 1 Sodium Potassium ATPase antibody [464.6] - Plasma Membrane Loading Control

Size: 100µg
Anti-alpha 1 Sodium Potassium ATPase antibody [464.6] (ab7671) is a mouse monoclonal antibody detecting alpha 1 Sodium Potassium ATPase in Western Blot, IHC-P, ICC/IF . Suitable for Human, Mouse, Pig, Rabbit, Rat . - Over 350 publications - Trusted since 2001
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:464.6,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Mouse, Rat, Rabbit, Human, Pig,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Anti-alpha 1 Sodium Potassium ATPase antibody [464.6] (ab7671) is a House Mouse Monoclonal antibody and is validated for use in ICC/IF, IHC-P, WB in human, rat samples.
Anti-alpha 1 Sodium Potassium ATPase antibody [464.6] (ab7671) has been cited over 357 times in peer reviewed journals and is trusted by the scientific community.
Abcams high quality validation processes ensure Anti-alpha 1 Sodium Potassium ATPase antibody [464.6] (ab7671) has high sensitivity and specificity.
Anti-alpha 1 Sodium Potassium ATPase antibody [464.6] (ab7671) has 41 independent reviews from customers.
Anti-alpha 1 Sodium Potassium ATPase antibody [464.6] (ab7671) specifically detects alpha 1 Sodium Potassium ATPase (UniProt ID: Q9N0Z6; Molecular weight: 113kDa) and is sold in 100 ug selling sizes.
Conjugation-ready, carrier free format available for antibody clone 464.6 -
ab237969
Antibody clone 464.6 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 647, HRP, Alexa Fluor® 488 (
ab196695
ab196696
ab197496
Alpha 1 Sodium Potassium ATPase (ATP1A1) is a critical enzyme involved in ion transport and maintaining electrolyte balance. The Na/K ATPase antibody (ATP1A1 antibody) is an essential tools for studying this enzyme's function. Abnormalities in ATP1A1 are linked to various diseases, including cardiovascular disorders and neurological conditions. Monitoring ATP1A1 levels can provide valuable insights into disease mechanisms and therapeutic targets.
This antibody clone [464.6] is manufactured by Abcam.
If you require this antibody in a different buffer formulation or a different conjugate for your experiments, please contact
orders@abcam.com
or you can find further information

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 6.97% L-Arginine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The alpha 1 Sodium Potassium ATPase often called Na+/K+ ATPase or Na K ATPase plays a critical role in cellular processes by maintaining the electrochemical gradients of sodium (Na+) and potassium (K+) across the plasma membrane. Also known as ATP1 or anti sodium this enzyme facilitates the active transport of Na+ and K+ ions against their concentration gradients a vital function for cellular homeostasis. The molecular weight of this enzyme is approximately 112 kDa with expression observed in various tissues including neuronal and muscular tissues indicating its importance in both central and peripheral cellular functions.
Biological function summary
The alpha 1 Sodium Potassium ATPase establishes ionic balance and is a component of the larger Na K ATPase complex which comprises multiple subunits. This complex not only aids in nerve impulse transmission but also supports muscle contraction and intracellular fluid regulation. Through its activity it significantly influences cellular volume and internal osmotic conditions thereby affecting overall tissue functionality.
Pathways
Alpha 1 Sodium Potassium ATPase is an important player in ion transport and cellular signaling pathways. It closely interacts with pathways such as the renin-angiotensin-aldosterone system and is vital for maintaining blood pressure homeostasis. The enzyme also interacts with several proteins including ankyrin and phospholemman which modulate its activity and are integral to various signaling cascades involved in cardiovascular and renal function.
The dysregulation of alpha 1 Sodium Potassium ATPase activity is linked to conditions like hypertension and congestive heart failure. Malfunctions in this enzyme can lead to improper ionic balance contributing to these diseases. The enzyme interacts with other proteins such as aldosterone synthase in hypertension and these interactions are critical in understanding their pathogenic mechanisms. A greater understanding of these associations may guide therapeutic strategies targeting ion transport abnormalities.