Abcam, ab76783, Anti-TMEM163 antibody

Size: 200µL
Rabbit Polyclonal TMEM163 antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TMEM163.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TMEM163. The exact immunogen used to generate this antibody is proprietary information.Q8TC26

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM163 also known as Transmembrane Protein 163 acts as a cation channel involved in zinc transport. This protein has a mass of approximately 24 kDa. TMEM163 is widely expressed in several tissues including brain heart and kidneys. Its distribution highlights its participation in various cellular processes that rely on metal ion homeostasis. Within the cell TMEM163 is localized to the membranes working in important areas that require regulated ion flow.
Biological function summary
TMEM163 plays a role in maintaining intracellular zinc levels which is significant for enzyme activation and cell signaling. It does not typically form part of a large protein complex but interacts with cellular structures as an independent entity. The ability of TMEM163 to transport zinc ions positions it as an important player in metal ion homeostasis impacting numerous cellular functions where zinc is a cofactor.
Pathways
TMEM163 contributes to pathways linked to metal ion homeostasis and signal transduction. It associates with proteins such as CDF family members which are known for their roles in zinc ion transport. Although not deeply integrated into regulatory pathways TMEM163's function influences the availability of zinc ions which are important for processes such as apoptosis and cell proliferation both modulated by signal transduction cascades.
TMEM163 links to neurological conditions and metal ion imbalance disorders. Altered expression of TMEM163 has been found in conditions like Alzheimer's disease. It interacts with proteins such as amyloid precursor protein which is involved in the pathology of Alzheimer's. Additionally disruptions in TMEM163 functionality potentially contribute to zinc-related metabolic disorders affecting cellular processes dependent on proper metal ion concentrations.