Abcam, ab76901, Anti-ZCCHC6 antibody

Size: 50µg
Mouse Polyclonal ZCCHC6 antibody. Carrier free. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Human TUT7.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Human TUT7.Q5VYS8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZCCHC6 also known as Zinc finger CCHC-type containing 6 is a protein that binds RNA and has a mass of about 66 kDa. It belongs to the terminal uridylyl transferase (TUTases) family and functions by adding uridines to the 3' end of RNA substrates. This protein shows expression in multiple tissues including the brain testes and ovaries reflecting its potential involvement in diverse cellular processes.
Biological function summary
ZCCHC6 contributes to RNA metabolism influencing RNA stability translation and degradation. It participates in the post-transcriptional regulation of gene expression by adding uridines to mRNA and non-coding RNAs which can impact the decay and processing of these RNA molecules. ZCCHC6 is also part of a dynamic complex that includes components like poly(A) polymerases interacting with various cofactors to modulate RNA length and stability.
Pathways
The processes involving ZCCHC6 play significant roles in RNA processing pathways and in the regulation of gene expression. Its activity contributes to the RNA surveillance pathway which ensures the quality control of RNA transcripts. ZCCHC6 interacts with other key proteins such as ZCCHC11 which shares similar protein domains and functions in RNA uridylation reinforcing its cooperation in these pathways.
ZCCHC6 influences conditions linked to RNA dysregulation such as certain cancers and neurodegenerative diseases. The protein plays a role in maintaining RNA quality and abundance and disturbances in its function can lead to abnormal RNA profiles observed in these disorders. In cancer for example aberrant activity of ZCCHC6 might disrupt normal cell regulatory mechanisms potentially interacting with proteins like LIN28 to promote oncogenic processes.