Abcam, ab76947, Anti-DDX54 antibody

Size: 100µL
Rabbit Polyclonal DDX54 antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human DDX54.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DDX54. The exact immunogen used to generate this antibody is proprietary information.Q8TDD1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab76947 was affinity purified using an epitope specific to DDX54 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DDX54 also known as DEAD Box Polypeptide 54 or DP97 is an ATP-dependent RNA helicase that belongs to the DEAD box family. It plays a mechanical role in the unwinding and remodeling of RNA secondary structures facilitating various RNA metabolic processes. This protein has a molecular mass of approximately 82 kDa and expresses widely in various tissues including the liver and brain. Its function is critical for maintaining normal cellular physiology by participating in processes like transcription regulation and ribosome biogenesis.
Biological function summary
DDX54 interacts with nuclear hormone receptors such as the Estrogen receptor to modulate gene expression. It acts as a coregulator in this context affecting transcriptional regulation and cellular response to hormones. This protein forms part of a multiprotein complex that functions in transcriptional machinery highlighting its integration into larger structural and functional frameworks within the cell. Through these interactions DDX54 significantly impacts cellular growth differentiation and response to external stimuli.
Pathways
DDX54 plays an important role in the steroid hormone receptor signaling pathway and the ribosome biogenesis pathway. It interacts with proteins including the Estrogen receptor and other coregulators influencing the expression of genes involved in cell proliferation and metabolism. These interactions position DDX54 as a critical node in cellular communication affecting pathways that manage cellular growth and maintenance.
DDX54 has associations with breast cancer and neurodegenerative diseases. In breast cancer it interacts with the Estrogen receptor influencing estrogen-responsive genes that can drive tumor progression. Its role in neurodegenerative diseases involves regulating stress response pathways where misregulated RNA processing might contribute to disease pathology. Connections to other proteins implicated in these diseases highlight its potential as a therapeutic target for intervention.