Abcam, ab77085, Anti-ZBRK1 antibody

Size: 100µg
Rabbit Polyclonal ZBRK1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ZNF350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZNF350. The exact immunogen used to generate this antibody is proprietary information.Q9GZX5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZBRK1 also known as ZNF350 is a zinc finger protein with a mass of approximately 61 kDa. It functions as a transcriptional repressor regulating gene expression by binding to specific DNA sequences. This protein is expressed in various tissues with notable levels observed in the brain lungs and reproductive organs. ZBRK1 interacts with other proteins to modulate its transcriptional activity playing an important role in the precise control of genetic information.
Biological function summary
The ZBRK1 protein plays a significant role in DNA damage response and cell cycle regulation. It often forms a complex with BRCA1 aiding in the repair of damaged DNA and maintaining genomic stability. This interaction suggests an involvement in regulating cell proliferation and preventing the accumulation of genetic mutations that could otherwise lead to oncogenic transformation. ZBRK1's ability to repress transcription of certain genes ensures controlled cell growth and division.
Pathways
ZBRK1 is integrally involved in the DNA damage response pathway and the p53 signaling pathway. In the DNA damage response pathway ZBRK1 works alongside BRCA1 to repair double-strand breaks through homologous recombination a critical process for maintaining genetic fidelity. Within the p53 signaling pathway ZBRK1 influences the expression levels of genes involved in cell cycle arrest and apoptosis relating it to proteins such as p21 which mediates cell cycle inhibition.
ZBRK1 holds connections to breast cancer and ovarian cancer. Mutations or dysregulation in ZBRK1 can affect its interaction with BRCA1 impairing DNA repair mechanisms and predisposing cells to oncogenic transformations. The defective repair of DNA can lead to genetic instability a hallmark of cancer progression. Moreover abnormalities in the pathways involving ZBRK1 are associated with changes in cell cycle control and apoptotic processes aligning with the development of malignant tumors.