Abcam, ab77098, Anti-Muscarinic Acetylcholine Receptor 1/CHRM1 antibody

Size: 100µg
Goat Polyclonal Muscarinic Acetylcholine Receptor 1/CHRM1 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human CHRM1 aa 400 to C-terminus.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CHRM1 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P11229

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab77098 is purified from goat serum by ammonium sulphate precipitation, followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Muscarinic Acetylcholine Receptor 1 (CHRM1) is a G protein-coupled receptor that plays an important role in transmitting acetylcholine-mediated cholinergic signals. It also goes by the names 'M1 receptor' or 'muscarinic acetylcholine receptors'. The protein has a mass of approximately 51 kDa and is largely expressed in the central nervous system particularly in the cerebral cortex and hippocampus. Its activation leads to intracellular signaling cascades involving the modulation of ion channels and influencing cellular responses.
Biological function summary
CHRM1 participates in various neural functions by interacting with acetylcholine. It does not form part of a complex itself but has significant interactions with other proteins particularly in nerve cells influencing cognitive processes and memory. CHRM1 plays an essential role in modulating neurotransmission which affects neuronal excitability and synaptic plasticity contributing to learning and attention processes.
Pathways
CHRM1 is involved in the phosphoinositide pathway and modulation of the MAPK/ERK pathway. The receptor interacts with proteins like Gq and G11 family members during signal transduction. These pathways help mediate the cellular actions initiated by neurotransmitter binding therefore facilitating long-term potentiation and contributing to cognitive function and higher brain activities.
CHRM1 is associated with Alzheimer's disease and schizophrenia. Altered signaling or expression of this receptor often correlates with cognitive decline in Alzheimer's disease suggesting a significant role in neurodegenerative processes. In schizophrenia dysfunctional CHRM1 signaling may impact thought processes and behavioral symptoms. In these contexts CHRM1 is connected to proteins such as beta-amyloid in Alzheimer's and dopamine receptors in schizophrenia pointing to its relevance in these conditions' molecular pathology.