Abcam, ab77273, Anti-Enkephalin/ENK antibody

Size: 100µg
Goat Polyclonal Enkephalin antibody. Suitable for WB, IHC-FoFr and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-FoFrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Enkephalin also known as ENK is a pentapeptide involved in regulating pain and emotion. It exists in two main forms: Leu-enkephalin and Met-enkephalin with molecular masses of 555.62 g/mol and 573.66 g/mol respectively. ENK peptides are primarily expressed in the central nervous system particularly in regions such as the thalamus hypothalamus and basal ganglia. They bind to opioid receptors especially the delta and mu receptors to modulate neurotransmission.
Biological function summary
Enkephalins play an important role in modulating pain perception and stress response. They do not operate alone but rather as components of a dynamic system involving other endogenous opioids and neuromodulators. Enkephalins participate in analgesic effects by binding to opioid receptors inhibiting neurotransmitter release and reducing neuronal excitability. Their interaction with other neurotransmitters including serotonin and norepinephrine suggests a broader role in emotional regulation and mood balance.
Pathways
Enkephalins engage in the opioid signaling pathway which influences pain and emotional states. This pathway interacts closely with the dopamine pathway where enkephalins modulate dopamine neurotransmission in areas related to reward and motivation. Other proteins such as the opioid receptors and prodynorphin play essential roles alongside enkephalins in these pathways contributing to complex interactions affecting mood and behavior.
Enkephalins relate to addiction and chronic pain conditions. They influence the rewarding effects of addictive substances interacting with dopamine receptor systems that can lead to dependency. Furthermore their involvement in pain pathways makes them relevant to the understanding and treatment of chronic pain disorders. Proteins like dynorphin another opioid peptide also link to these conditions often interacting with enkephalins to modulate pain and emotional response.