Abcam, ab77625, Anti-carabin antibody

Size: 200µL
Goat Polyclonal carabin antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human TBC1D10C aa 400 to C-terminus.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TBC1D10C aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8IV04

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab77625 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 0.5% BSA, 0.5% Tris buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Carabin also known as TBC1D10C functions as a signaling protein involved in the regulation of T-cell activation and calcium signaling. It has a molecular mass of approximately 40 kDa. This protein is expressed across various tissues with significant expression in immune system cells such as T-cells. Carabin interacts with other proteins within cells to control processes that are vital for maintaining proper immune responses.
Biological function summary
Carabin acts as a negative regulator for the calcineurin-NFAT signaling pathway helping to control immune cell activation. It binds to calcineurin inhibiting its phosphatase activity which in turn reduces NFAT transcription factor activation. Carabin forms part of complexes within cells including those involving proteins like Ras which further modulates its regulatory functions. These interactions place carabin as an important protein in the context of immune system modulation and response.
Pathways
Carabin participates in T-cell receptor (TCR) signaling and calcium signaling pathways. The interaction with calcineurin links carabin to the regulation of the immune response especially in T-cell signaling and activation. It relates to proteins such as NFAT and Ras coordinating responses that control the transcription of genes important for immune cell function. This positioning in pathways highlights carabin's role in ensuring immune homeostasis.
Carabin's malfunction or dysregulation can impact immune-related conditions including autoimmune diseases and immunodeficiencies. Alterations in carabin expression or activity have connections to increased risk of autoimmune disorders where the immune system misfires against the body's own cells. Carabin's interactions with proteins like calcineurin and NFAT are important in understanding immune imbalance which could guide therapeutic strategies for such conditions.