Abcam, ab78323, Anti-EID1 antibody [26]

Size: 100µL
Mouse Monoclonal EID1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human EID1 aa 150 to C-terminus.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:26,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human EID1 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9Y6B2

Properties and Storage Information:
Form-Liquid, Purification technique-Ion exchange chromatography, Purification notes-ab78323 was purified by propriety chromatography under mild conditions as IgG fraction from serum free growth medium of mouse hybridoma clone and sterilized by filtration., Storage buffer-pH: 6 - 8.5Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EID1 also known as EP300 interacting inhibitor of differentiation 1 is a nuclear protein involved in transcriptional regulation. It has a molecular mass of approximately 22 kDa. EID1 primarily expresses in various tissues and acts as a co-regulator by interacting with transcription factors and modifying the transcription process. Its ability to bind with different cofactors allows it to play a role in multiple cellular functions.
Biological function summary
EID1 modulates transcriptional repression and differentiation processes. It participates in complexes with other proteins such as histone deacetylases and methyltransferases to alter chromatin structure and gene expression. EID1 can inhibit the activity of certain transcription factors influencing cell cycle progression and developmental pathways. In these roles EID1 exerts a substantial impact on cellular differentiation and proliferation.
Pathways
EID1 significantly impacts pathways like retinoblastoma (RB) and Wnt signaling. In the RB pathway EID1 modulates cell cycle control by interacting with proteins like p300/CBP. EID1's role in the Wnt signaling pathway involves influencing β-catenin activity which impacts cell fate determination and stem cell renewal. These interactions highlight EID1's role in signaling cascades that regulate proliferation and differentiation.
EID1 associates with cancer and neurodegenerative diseases. In cancer EID1 can alter tumor suppressor pathways by interacting with proteins such as p300 potentially affecting the tumor's growth and progression. In neurodegenerative diseases its role in gene expression modulation may result in atypical cellular functions that contribute to disease development. EID1's interactions with various co-regulators make it a target for research in diseased states.