Abcam, ab79046, Anti-MEX3A antibody

Size: 100µg
Rabbit Polyclonal MEX3A antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 20 publications. Immunogen corresponding to Synthetic Peptide within Human MEX3A.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MEX3A. The exact immunogen used to generate this antibody is proprietary information.A1L020

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Affinity chromatography purified via peptide column, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The MEX3A protein also known as Mex-3 RNA-binding protein A is a member of the RNA-binding protein family characterized by the presence of two K homology (KH) domains. It has a molecular mass of approximately 60 kDa. MEX3A is expressed in various human tissues including the small intestine colon and stomach. The protein functions mechanically as an RNA-binding protein that regulates the stability and translation of target mRNAs impacting gene expression at a post-transcriptional level.
Biological function summary
The MEX3A protein plays roles in cell differentiation and proliferation by influencing mRNA dynamics. It operates independently rather than as a part of a larger protein complex. MEX3A regulates the expression of key developmental and cell cycle-related genes aiding in cellular function and tissue homeostasis. The protein's ability to modulate mRNA transcripts makes it a significant player in maintaining proper cellular response to environmental changes.
Pathways
Studies show that MEX3A plays a role in the Wnt signaling and Notch signaling pathways. In the Wnt signaling pathway it affects the stability of mRNAs related to cell growth and differentiation. Through the Notch signaling pathway MEX3A interacts with various proteins such as DVL3 influencing decisions in cell fate and proliferation. These pathways highlight MEX3A's involvement in important processes of development and cellular communication.
MEX3A is associated with colorectal cancer and gastric cancer. Abnormal expression or mutation of the MEX3A protein may contribute to the progression of these cancers by disrupting normal mRNA regulation leading to uncontrolled cell growth. In colorectal cancer MEX3A interacts with proteins like β-catenin further emphasizing its role in aberrant Wnt signaling. Through its contributions to critical pathways MEX3A serves as a potential biomarker and therapeutic target in oncology research.