Abcam, ab79067, Anti-JP-4 antibody

Size: 100µg
Rabbit Polyclonal JP-4 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human JPH4.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human JPH4. The exact immunogen used to generate this antibody is proprietary information.Q96JJ6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Affinity chromatography purified via peptide column, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
JP-4 also known as Junction Protein-4 is a 45 kDa protein that functions mechanically as a structural component in cellular junctions. It is expressed primarily in epithelial cells and assists in maintaining cell-cell adhesion and integrity. The protein is also seen in neural tissues where it plays a similar role in facilitating intercellular connections.
Biological function summary
JP-4 contributes to cellular communication and tissue stability through its involvement in cell junction assembly. It often forms part of a complex with other junctional proteins enhancing the strength and coordination of cellular connections. This protein stabilizes junctional connections ensuring effective communication between adjacent cells and maintaining tissue homeostasis.
Pathways
Cellular adhesion pathways and neural signaling processes incorporate JP-4. It interacts within the cadherin-mediated cell junction pathway associating with proteins such as E-cadherin and beta-catenin and aids in mediating adhesive interactions critical for tissue architecture. Additionally JP-4 involvement in neural pathways suggests a role in synaptic stability and neurotransmitter fluidity.
Abnormalities in JP-4 have associations with epithelial barrier dysfunctions and neurodegenerative conditions. In inflammatory bowel disease dysfunctional JP-4 disrupts epithelial barriers impairing digestive system integrity. Its interactions with neural proteins such as synapsin indicate potential links to disorders like Alzheimer's disease where synaptic connections deteriorate.