Abcam, ab79523, PE Anti-HLA A2 antibody [BB7.2]

Size: 100Test
Mouse Monoclonal HLA A antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human HLA-A.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:BB7.2,
Isotype:IgG2b,
Conjugation:PE,
Excitation/Emission:Ex: 480;565nm, Em: 578nm,
Carrier free:No,
Reacts with:Human,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Human HLA-A.P04439,
Epitope:This antibody recognizes an epitope at the C-terminus of alpha-2 helix and a turn on one of the underlying beta strands within the human HLA A2 histocompatibility antigen.

Properties and Storage Information:
Form-Liquid, Purification technique-Size-exclusion chromatography, Storage buffer-pH: 7.4Preservative: 0.097% Sodium azideConstituents: PBS, 0.2% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target protein HLA A2 also known as HLA-A*0201 is an essential human leukocyte antigen (HLA) class I molecule. It plays a central role in the immune system by presenting endogenously processed antigens to CD8+ T cells. The molecular weight of HLA A2 is approximately 45 kDa. This protein is expressed on almost all nucleated cells and interacts with β2-microglobulin which is necessary for its stability and transport to the cell surface.
Biological function summary
HLA A2 contributes to the adaptive immune response by presenting antigenic peptides derived from intracellular proteins to CD8+ cytotoxic T lymphocytes. It forms a heterotrimeric complex that includes HLA heavy chain β2-microglobulin and a peptide of approximately 8-10 amino acids. This complex is fundamental for the recognition of infected or transformed cells facilitating their destruction by the immune system.
Pathways
The target engages in immune response pathways especially the antigen processing and presentation pathway. It shares functions with other HLA class I molecules such as HLA-B and HLA-C which together coordinate the presentation of a diverse array of peptides to cytotoxic T cells. Moreover HLA A2 plays a role in the T-cell receptor signaling pathway which is important for the activation of immune responses.
HLA A2 has associations with several conditions including certain autoimmune diseases and cancers. Specifically it is linked to diseases like multiple sclerosis and melanoma where it influences the presentation of self or tumor antigens affecting immune system targeting. In these contexts HLA A2 interacts with other immune system components such as PD-L1 in melanoma which can modulate immune checkpoint pathways and impact disease progression.