Abcam, ab79742, Recombinant human PARP11 protein

Size: 10µg
Recombinant human PARP11 protein is a Human Full Length protein, expressed in Baculovirus infected Sf9 cells, with >80%, suitable for SDS-PAGE, WB, FuncS.
Key facts
Purity:>80% SDS-PAGE,
Expression system:Baculovirus infected Sf9 cells,
Tags:Tag free,
Applications:SDS-PAGE, WB, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:Specific Activity: 23 U/mg.,
Accession:Q9NR21,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 50% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.395% Tris HCl, 0.05% Sorbitan monolaurate, ethoxylated, 0.0462% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PARP11 also known as Poly (ADP-ribose) Polymerase 11 is an enzyme involved in regulating protein function through mono-ADP-ribosylation a post-translational modification. The protein has a molecular mass of about 40 kDa. PARP11 is expressed in various tissues notably in the liver and immune system cells. This enzyme plays a role in establishing cellular processes linked to protein stability and signaling.
Biological function summary
PARP11 modifies proteins by adding ADP-ribose units impacting their interaction and activity. It is not part of a large complex but works on its own. Its activity influences cellular responses to stress and can alter how cells communicate and survive under adverse conditions. These functions highlight its significance in controlling immune responses and inflammation.
Pathways
PARP11 contributes to the regulation of the NF-kB signaling and interferon pathways. These pathways are essential for immune function and inflammation control. PARP11 interacts with other proteins like PARP1 in the NF-kB pathway impacting transcriptional activity and inflammatory responses. Its actions help modulate cellular responses to DNA damage and stress signals.
PARP11 has been connected to cancer and autoimmune diseases. Changes in its activity can influence tumor growth and immune responses making it an attractive target in cancer and autoimmune disease research. Its interaction with proteins like PARP1 often contributes to these pathological conditions suggesting that targeting PARP11 might offer therapeutic benefits in managing these diseases.